Diabetic nephropathy is a relatively complex and comprehensive disease at different stages of diabetic nephropathy by different methods. Only on the basis of targeted treatment of different periods, will be more effective. So diabetic nephropathy is how in the clinical staging. Here we look at hope for the treatment of patients with diabetic nephropathy provide some help.
The following five points to guide clinical treatment and prognosis.
A: increased glomerular filtration rate and renal volume increase for the characteristics of newly diagnosed IDDM patients to have this change, while renal blood flow and glomerular capillary perfusion pressure and the pressure increased.
Two: the period of normoalbuminuria. This period of normal urinary albumin excretion rate (less than 20 micrograms / min or 30 mg / 24 hours), UAE increased after exercise but return to normal after rest. This period of glomerular structural changes have occurred, GBM thickening and mesangial matrix increase.
Three: mildly elevated blood pressure in early diabetic nephropathy. The patients with slightly elevated blood pressure, lower blood pressure can be partially reduced urinary albumin excretion. The patient's GBM thickening and mesangial matrix increase is more obvious, there are nodular and diffuse glomerular lesions and hyaline degeneration of small arteries and glomeruli have begun to appear abandoned.
Four: clinical diabetic nephropathy or overt diabetic nephropathy. This period is characterized by a large number of albumin, urinary protein consistently greater than 0.5 g per 24 hours non-selective proteinuria, severe proteinuria greater than 2.0 g per 24 hours. With the large number of urinary protein loss can occur hypoalbuminemia and edema. Blood pressure. Thickened GBM patients, mesangial matrix widening, increased glomerular abandoned.
Five: the end-stage renal failure. Once diabetic patients develop persistent proteinuria clinical diabetic nephropathy, due to widespread thickening of the glomerular basement membrane, glomerular capillary cavity of the narrow and more glomerular abandoned, decreased kidney filtration function, causing azotemia and renal failure, more than the last patient's GFR <10ml/min, serum creatinine and urea nitrogen levels, with severe hypertension, hypoalbuminemia, edema, loss of appetite, nausea and vomiting secondary to uremia neuropathy and cardiomyopathy.
As each body of diabetic patients is different, so the rate of progression of the disease are not the same. However, diabetic patients need to understand their stage of diabetic nephropathy in which. So as to develop their own treatment, control disease, prevent disease complications appear.
The following five points to guide clinical treatment and prognosis.
A: increased glomerular filtration rate and renal volume increase for the characteristics of newly diagnosed IDDM patients to have this change, while renal blood flow and glomerular capillary perfusion pressure and the pressure increased.
Two: the period of normoalbuminuria. This period of normal urinary albumin excretion rate (less than 20 micrograms / min or 30 mg / 24 hours), UAE increased after exercise but return to normal after rest. This period of glomerular structural changes have occurred, GBM thickening and mesangial matrix increase.
Three: mildly elevated blood pressure in early diabetic nephropathy. The patients with slightly elevated blood pressure, lower blood pressure can be partially reduced urinary albumin excretion. The patient's GBM thickening and mesangial matrix increase is more obvious, there are nodular and diffuse glomerular lesions and hyaline degeneration of small arteries and glomeruli have begun to appear abandoned.
Four: clinical diabetic nephropathy or overt diabetic nephropathy. This period is characterized by a large number of albumin, urinary protein consistently greater than 0.5 g per 24 hours non-selective proteinuria, severe proteinuria greater than 2.0 g per 24 hours. With the large number of urinary protein loss can occur hypoalbuminemia and edema. Blood pressure. Thickened GBM patients, mesangial matrix widening, increased glomerular abandoned.
Five: the end-stage renal failure. Once diabetic patients develop persistent proteinuria clinical diabetic nephropathy, due to widespread thickening of the glomerular basement membrane, glomerular capillary cavity of the narrow and more glomerular abandoned, decreased kidney filtration function, causing azotemia and renal failure, more than the last patient's GFR <10ml/min, serum creatinine and urea nitrogen levels, with severe hypertension, hypoalbuminemia, edema, loss of appetite, nausea and vomiting secondary to uremia neuropathy and cardiomyopathy.
As each body of diabetic patients is different, so the rate of progression of the disease are not the same. However, diabetic patients need to understand their stage of diabetic nephropathy in which. So as to develop their own treatment, control disease, prevent disease complications appear.
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