Currently, more and more patients with diabetes use insulin therapy. According to the 2003 Group of China, cooperation in the investigation report shows that the proportion of patients treated with insulin five years increased by 15%. 2005 International Diabetes Federation (IDF) launches the global fight against type 2 diabetes guidelines that, when oral hypoglycemic medications and lifestyle interventions can not make blood glucose should begin insulin therapy. In addition, when the maximum dose of oral medication and has to remain greater than 7.5% glycated hemoglobin, they should start insulin therapy. Thus, how to improve insulin action, improve treatment, reduce the dose, reduce treatment costs, mitigate potential adverse effects, for many patients with diabetes concerns.
Weight control
Overweight and obesity is caused by insulin resistance and reduced insulin sensitivity in the body of the important reasons. Diabetes through a reasonable diet, healthy habits, appropriate exercise to reduce excessive weight is an important measure to improve insulin sensitivity, but also a good way to be effective. Often see clinically obese diabetic patients lose weight, blood glucose control becomes easier, and the gradual decrease in the insulin dose. Weight reduction and improved insulin resistance but also help reduce the burden of islet cells secrete insulin, to a certain extent, to protect the ability of endogenous insulin secretion.
Develop good exercise habits
Appropriate exercise can help to promote insulin play a role in accelerating the body-related organizations such as muscle, fat and other glucose utilization. Note that, to choose their own physical condition of exercise, physical activity should be appropriate to avoid hypoglycemia and excessive movement of the body caused by over-consumption, decreased immunity and so on.
Reasonable distribution of the meal insulin dose
Insulin is a hormone that helps the body to glucose, but elevated blood sugar hormones such as glucagon, growth hormone, corticosteroids, adrenaline, insulin has a biological role of antagonism. The glucagon secretion in the human evolutionary process, has formed its own secretion, such as dawn and early morning this time the role of glucagon and strong, or even result in the so-called "dawn phenomenon", that early morning high blood sugar. Therefore, the dose of insulin before breakfast may be increased, lunch and dinner before the dose can be reduced accordingly.
Actively control the stress
If there are other acute physical or emotional illness, due to sympathetic and glucagon secretion, will diminish the role of insulin. Therefore, aggressive treatment with disease should learn to control their emotions and maintain a healthy mental state, in order to facilitate the treatment of diabetes.
Use the appropriate insulin dosage
Human insulin, animal insulin to help change the efficacy of insulin play, reduce adverse reactions and the body's immune response to foreign proteins. In addition, the use of human insulin to human insulin analogues will also be used to improve the therapeutic effect of insulin, insulin analogues because of the absorption and distribution more in line with the physiological state of insulin secretion, and its compliance and security are better.
Use of insulin sensitizers
These drugs are mainly thiazolidinediones, TZDs and biguanide drugs. Current clinical use, the former rosiglitazone, pioglitazone, etc., which are mainly metformin. Mechanism of action of these drugs is to increase muscle and fat tissue to insulin sensitivity, insulin resistance, and promote the role of insulin, thereby reducing the insulin dose.
Aggressive treatment of metabolic disorders
Diabetes is the accumulation of a variety of metabolic abnormalities status, patients with diabetes tend to exist in fact a variety of metabolic abnormalities. Some patients are the metabolic syndrome itself, the existence of such patients are also abnormal lipid metabolism, blood viscosity state, and even high blood sugar itself has toxic effects on the body. For example, toxic or high-fat high-sugar toxicity itself can damage both the endogenous insulin secretion, and also promote the body's insulin resistance, or reduce the biological effect of insulin. Therefore, the positive control of metabolism will greatly improve the body's condition is conducive to insulin play a role.
Weight control
Overweight and obesity is caused by insulin resistance and reduced insulin sensitivity in the body of the important reasons. Diabetes through a reasonable diet, healthy habits, appropriate exercise to reduce excessive weight is an important measure to improve insulin sensitivity, but also a good way to be effective. Often see clinically obese diabetic patients lose weight, blood glucose control becomes easier, and the gradual decrease in the insulin dose. Weight reduction and improved insulin resistance but also help reduce the burden of islet cells secrete insulin, to a certain extent, to protect the ability of endogenous insulin secretion.
Develop good exercise habits
Appropriate exercise can help to promote insulin play a role in accelerating the body-related organizations such as muscle, fat and other glucose utilization. Note that, to choose their own physical condition of exercise, physical activity should be appropriate to avoid hypoglycemia and excessive movement of the body caused by over-consumption, decreased immunity and so on.
Reasonable distribution of the meal insulin dose
Insulin is a hormone that helps the body to glucose, but elevated blood sugar hormones such as glucagon, growth hormone, corticosteroids, adrenaline, insulin has a biological role of antagonism. The glucagon secretion in the human evolutionary process, has formed its own secretion, such as dawn and early morning this time the role of glucagon and strong, or even result in the so-called "dawn phenomenon", that early morning high blood sugar. Therefore, the dose of insulin before breakfast may be increased, lunch and dinner before the dose can be reduced accordingly.
Actively control the stress
If there are other acute physical or emotional illness, due to sympathetic and glucagon secretion, will diminish the role of insulin. Therefore, aggressive treatment with disease should learn to control their emotions and maintain a healthy mental state, in order to facilitate the treatment of diabetes.
Use the appropriate insulin dosage
Human insulin, animal insulin to help change the efficacy of insulin play, reduce adverse reactions and the body's immune response to foreign proteins. In addition, the use of human insulin to human insulin analogues will also be used to improve the therapeutic effect of insulin, insulin analogues because of the absorption and distribution more in line with the physiological state of insulin secretion, and its compliance and security are better.
Use of insulin sensitizers
These drugs are mainly thiazolidinediones, TZDs and biguanide drugs. Current clinical use, the former rosiglitazone, pioglitazone, etc., which are mainly metformin. Mechanism of action of these drugs is to increase muscle and fat tissue to insulin sensitivity, insulin resistance, and promote the role of insulin, thereby reducing the insulin dose.
Aggressive treatment of metabolic disorders
Diabetes is the accumulation of a variety of metabolic abnormalities status, patients with diabetes tend to exist in fact a variety of metabolic abnormalities. Some patients are the metabolic syndrome itself, the existence of such patients are also abnormal lipid metabolism, blood viscosity state, and even high blood sugar itself has toxic effects on the body. For example, toxic or high-fat high-sugar toxicity itself can damage both the endogenous insulin secretion, and also promote the body's insulin resistance, or reduce the biological effect of insulin. Therefore, the positive control of metabolism will greatly improve the body's condition is conducive to insulin play a role.
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