Hsu retired teacher has been found to have diabetes, more than a year, according to doctor's request, he glibenclamide treatment of long-term use, coupled with diet control and usually have moderate exercise, his condition has been very stable, not only blood glucose control doing well and "a little" symptoms as well. A few days ago, the weather suddenly cold, some of his fever, will be its own medicine chest out Banlangen and taking aspirin.
Medication 3 days later, a cold'd healed, but he suddenly felt a black eyes, suddenly fainted, thanks to his family sent him to discover the hospital was out of danger by the medical emergency treatment. The doctor later told him that he is due to improper treatment of low blood sugar coma, if not caught early, there is dangerous.
That a person can use two or more kinds of drugs called combination therapy, combination therapy, some drugs will be interference or influence of other drugs, that is cross-reactive drugs, the most common drug cross-reactivity is the antagonism of drugs and synergy.
In particular, diabetic patients with medication to be careful, because during the treatment of diabetes, while taking other drugs, may be due to these drugs easily with a tolbutamide, glibenclamide and other antidiabetic drugs antagonistic effect occurs, thereby reducing the efficacy of hypoglycemic drugs ; synergistic effect may also occur, so that blood sugar drop too low, or even to cause low blood sugar coma, if not timely detection and treatment, and sometimes life-threatening.
Diabetic patients taking hypoglycemic agents during the same time is best not to take the following drugs:
Aspirin oral hypoglycemic agents can slow down the metabolism and excretion will increase the efficacy of sulfonylurea drugs, combined with its hypoglycemic effect itself, the combination will make blood sugar drop too low, it can lead low blood sugar coma. Mr Xu hypoglycemia coma reason why.
Propranolol and other β-blocker propranolol can lower blood pressure, but also impede the release of glucose, glycogen, blood sugar decreased, it can also promote insulin secretion of insulin, it can cover up the increase in heart rate caused by low blood sugar such as signs, and oral hypoglycemic agents with the clothes, can cause low blood sugar coma. Therefore, people with diabetes to be very careful taking propranolol.
Anticoagulants such as dicoumarol, D860 inhibited the metabolism and prolong its half-life, easy hypoglycemia.
Chloramphenicol can inhibit hepatic drug metabolizing enzyme activity and reduce hypoglycemic drug metabolism, can lead to low blood sugar.
Cotrimoxazole can strengthen the role of oral hypoglycemic agents, application should adjust the dose of hypoglycemic agents.
Glucocorticoids such as prednisone, cortisone, dexamethasone, etc., these drugs can increase the synthesis of glycogen, reducing the use of tissue and decomposition of glycogen, so that blood sugar, so named glucocorticoids, banned drugs in patients with diabetes.
Anti-tuberculosis drugs isoniazid, rifampicin, they can promote liver enzymes secreted more of the drug metabolism and excretion of accelerated D860, D860 and thus shorten the half-life, hypoglycemic effect, reducing the efficacy of hypoglycemic agents, the blood sugar.
Estrogen, progesterone and oral contraceptives that they can reduce the efficacy of hypoglycemic agents.
Furosemide, Lee uric acid, hydrochlorothiazide and other diuretics in urine thiophene they can inhibit the secretion of insulin, so blood sugar.
Tetracycline, oxytetracycline, gentamicin, etc. can produce a large number of lactic acidosis caused by the patient.
Niacin can cause decreased glucose tolerance, peripheral tissue by inhibiting glucose utilization.
In addition, antipsychotics such as chlorpromazine, are nearly as excited with elevated blood glucose. Some should be used with caution in patients with severe diabetes, excess sugar sub-agents, such as various types of oral tablets, chewable tablets often added sugar as a sweetener because it contains more sugar, the drugs generally have the manual instructions. Avoid alcohol diabetic patients, mainly because of alcohol can inhibit the activity of hepatic drug metabolizing enzyme, causing low blood sugar.
Diabetic patients should be noted: When a diabetic has just changed the type and dose of oral medication and are taking other medicines, or you just taking an oral medication, but just used some over the counter, if not then your blood sugar apparent reason out of control, or high blood sugar, low blood sugar symptoms, you have to take into account possible cross-reaction of some drugs caused. If you suspect the influence of drugs other effects of oral diabetes should immediately see a doctor, doctor guide, do not self-blind dosing for drugs or otherwise, may result in adverse consequences.
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