Recently, the U.S. FDA and European regulatory authorities have to respond, for pyrrole rosiglitazone may increase the side effects caused by bladder cancer made a review of warning and alert doctors and patients in long-term endocrine large number of drugs caused sufficient vigilance is required.
Recalling the initial "Avandia" (rosiglitazone) event, following rosiglitazone may cause heart damage was broke and the shelf by the FDA after its "brothers" now pyrrole rosiglitazone has also been a certain degree of questioned. "XX rosiglitazone," Why hit repeatedly suffered side-effects? To address these issues, 39 health network consulting editor came Endocrinology, Nanfang Hospital Director Professor Xue Yaoming, let him come for us to answer these questions.
Experts:
XUE Yao-ming, Department of Endocrinology, Nanfang Hospital, Southern Medical University, director, professor, chief physician. 2006 Harvard University Diabetes Center at Harvard Medical School Jonslin postdoctoral work, and appointed Visiting Professor at Harvard Medical School. Has extensive teaching experience and training post-doctoral, doctoral and master more than 50. Endocrine and metabolic diseases in clinical, teaching and research for 20 years, in the diagnosis and treatment of endocrine and metabolic diseases have a broad solid theoretical foundation and rich clinical experience, diabetes, thyroid disease, gout, osteoporosis and metabolic endocrine disorders disease diagnosis and treatment are unique.
News Background:
Pyrrole rosiglitazone may increase the risk of bladder cancer in some countries has been disabled
According to foreign media reports, recently, France and Germany's drug regulatory department of a common diabetes drug, "pyrrole rosiglitazone," issued a restraining order, allegedly, in the United Kingdom reported 573 cases of "Ai Extension" (pyrrole rosiglitazone ) adverse reactions found in two patients suffering from bladder cancer, experts said, the results indicate that the drug associated with the incidence of bladder cancer may have a positive relationship ... ... Click for details
Pyrrole rosiglitazone and rosiglitazone is really the same drug
Enhance insulin sensitivity is double-edged sword
For pyrrole rosiglitazone and rosiglitazone are there side effects that have burst, Nanfang Hospital, Professor Xue Yaoming director of endocrinology, said the presence of side effects and the mechanism of drug action are very relevant.
Experts pointed out that the pyrrole rosiglitazone and rosiglitazone are insulin sensitizers are, through activating the nuclear receptor PPAR-γ, involved in glucose production, transport and use of insulin response to regulate gene transcription work, but The target of this gene is high in the produce pharmacological effects, it would also have some impact on the human body.
Professor Xue Yaoming said: "This is like a river, upstream of the river there is a problem, or if changed, the downstream impact is very broad!"
Pyrrole rosiglitazone good efficacy
Can not replace clinical
Pyrrole rosiglitazone for bladder cancer risk may exist, experts point out that now is too early to draw a conclusion on the possible side effects should be an objective view.
Professor Xue Yaoming that the clinical use of rosiglitazone and pyrrole rosiglitazone is widespread, the efficacy is very good, especially as an insulin sensitizer for type 2 diabetes patients with different degrees of insulin resistance, have very good results.
"Especially when multiple drugs in combination are not working well, adding pyrrole in the drug rosiglitazone, often play better control of blood sugar!" Professor Xue Yaoming said, "FDA will rosiglitazone (Avandia ) off the shelf, but the Chinese did not do so, also taking into account the rosiglitazone their pharmacological effects are very obvious, if not inherent in the heart failure patients, diabetic patients with normal and not a very big impact. pyrrole column ketone is the same as commonly used in clinical insulin sensitizer, no other drugs can replace it! "
The relationship between drugs and cancer require long-term observation
Now is too early to disabled
Experts said that evaluation of whether a drug may cause cancer, the whole process will take long-term observations, and not with a small number of cases to the conclusion!
Professor Xue Yaoming that foreign media reports, the occurrence of side effects rosiglitazone pyrrole 573 patients, 2 patients had bladder cancer, FDA also issued a public notice by the tips may be at risk, but it does not mean that rosiglitazone and pyrrole between certain tumor there is a relationship.
"Any evaluation of whether a drug may cause cancer, require long-term observation, two cases can be said that one example, the current domestic and abroad are concerned about the progress of events, in China there is no literature reports of induced tumors Case! "Professor Xue Yaoming said.
For pyrrole rosiglitazone is safe to use questions, experts said, FDA has not issued specific findings, ADA (American Diabetes Association) has not yet issued the relevant regulations prohibit the use. Professor Xue Yaoming said: "At this stage, also need to disable pyrrole rosiglitazone, Avandia is also not fully in clinical disabled, the key is, an objective evaluation of drug and balance the pros and cons, patients get too excited!"
Recalling the initial "Avandia" (rosiglitazone) event, following rosiglitazone may cause heart damage was broke and the shelf by the FDA after its "brothers" now pyrrole rosiglitazone has also been a certain degree of questioned. "XX rosiglitazone," Why hit repeatedly suffered side-effects? To address these issues, 39 health network consulting editor came Endocrinology, Nanfang Hospital Director Professor Xue Yaoming, let him come for us to answer these questions.
Experts:
XUE Yao-ming, Department of Endocrinology, Nanfang Hospital, Southern Medical University, director, professor, chief physician. 2006 Harvard University Diabetes Center at Harvard Medical School Jonslin postdoctoral work, and appointed Visiting Professor at Harvard Medical School. Has extensive teaching experience and training post-doctoral, doctoral and master more than 50. Endocrine and metabolic diseases in clinical, teaching and research for 20 years, in the diagnosis and treatment of endocrine and metabolic diseases have a broad solid theoretical foundation and rich clinical experience, diabetes, thyroid disease, gout, osteoporosis and metabolic endocrine disorders disease diagnosis and treatment are unique.
News Background:
Pyrrole rosiglitazone may increase the risk of bladder cancer in some countries has been disabled
According to foreign media reports, recently, France and Germany's drug regulatory department of a common diabetes drug, "pyrrole rosiglitazone," issued a restraining order, allegedly, in the United Kingdom reported 573 cases of "Ai Extension" (pyrrole rosiglitazone ) adverse reactions found in two patients suffering from bladder cancer, experts said, the results indicate that the drug associated with the incidence of bladder cancer may have a positive relationship ... ... Click for details
Pyrrole rosiglitazone and rosiglitazone is really the same drug
Enhance insulin sensitivity is double-edged sword
For pyrrole rosiglitazone and rosiglitazone are there side effects that have burst, Nanfang Hospital, Professor Xue Yaoming director of endocrinology, said the presence of side effects and the mechanism of drug action are very relevant.
Experts pointed out that the pyrrole rosiglitazone and rosiglitazone are insulin sensitizers are, through activating the nuclear receptor PPAR-γ, involved in glucose production, transport and use of insulin response to regulate gene transcription work, but The target of this gene is high in the produce pharmacological effects, it would also have some impact on the human body.
Professor Xue Yaoming said: "This is like a river, upstream of the river there is a problem, or if changed, the downstream impact is very broad!"
Pyrrole rosiglitazone good efficacy
Can not replace clinical
Pyrrole rosiglitazone for bladder cancer risk may exist, experts point out that now is too early to draw a conclusion on the possible side effects should be an objective view.
Professor Xue Yaoming that the clinical use of rosiglitazone and pyrrole rosiglitazone is widespread, the efficacy is very good, especially as an insulin sensitizer for type 2 diabetes patients with different degrees of insulin resistance, have very good results.
"Especially when multiple drugs in combination are not working well, adding pyrrole in the drug rosiglitazone, often play better control of blood sugar!" Professor Xue Yaoming said, "FDA will rosiglitazone (Avandia ) off the shelf, but the Chinese did not do so, also taking into account the rosiglitazone their pharmacological effects are very obvious, if not inherent in the heart failure patients, diabetic patients with normal and not a very big impact. pyrrole column ketone is the same as commonly used in clinical insulin sensitizer, no other drugs can replace it! "
The relationship between drugs and cancer require long-term observation
Now is too early to disabled
Experts said that evaluation of whether a drug may cause cancer, the whole process will take long-term observations, and not with a small number of cases to the conclusion!
Professor Xue Yaoming that foreign media reports, the occurrence of side effects rosiglitazone pyrrole 573 patients, 2 patients had bladder cancer, FDA also issued a public notice by the tips may be at risk, but it does not mean that rosiglitazone and pyrrole between certain tumor there is a relationship.
"Any evaluation of whether a drug may cause cancer, require long-term observation, two cases can be said that one example, the current domestic and abroad are concerned about the progress of events, in China there is no literature reports of induced tumors Case! "Professor Xue Yaoming said.
For pyrrole rosiglitazone is safe to use questions, experts said, FDA has not issued specific findings, ADA (American Diabetes Association) has not yet issued the relevant regulations prohibit the use. Professor Xue Yaoming said: "At this stage, also need to disable pyrrole rosiglitazone, Avandia is also not fully in clinical disabled, the key is, an objective evaluation of drug and balance the pros and cons, patients get too excited!"
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