Hypertension and diabetes is extremely harmful: the increasing degree of coronary atherosclerosis, the higher the incidence of coronary heart disease; medium-sized arteries (including carotid artery, aorta, coronary arteries, renal arteries, etc.) early appearance of atherosclerosis, increased levels ; not only increased macrovascular disease, microvascular disease is also increased; diabetes, elevated blood lipids, coagulation dysfunction (increased activity of plasminogen inhibitor), the hypertensive patients of the hypercoagulable state already exists to further increase, more susceptible to brain infarction; high blood pressure will accelerate the development of diabetic nephropathy, and accelerated the progress of diabetic nephropathy, further blood pressure will rise, creating a vicious cycle; further increase sodium and water retention, fat and sugar metabolism, not only peripheral vascular resistance increased, and vascular smooth muscle to norepinephrine (NE) and angiotensin Ⅱ (Ag Ⅱ) increased sensitivity to contraction, so that even more difficult to control blood sugar and blood pressure. 1999 WHO International Society of Hypertension (WHO-ISH) and the Ministry of Health and the Chinese Hypertension League, "Chinese Hypertension Prevention Guide" are to a (mild) hypertension, or blood pressure in the 140-159/90-99 mm Hg with diabetes were included in the high cardiovascular risk group, and severe hypertension (≥ 180/110 mmHg) the same as the.
In recent years, large clinical trial published in the report, such as systolic blood pressure of old age, systolic hypertension in Europe trial, hypertension optimal treatment trial of hypertension in diabetes study risk factors for acute myocardial infarction, etc., have been clearly demonstrated , diabetes and hypertension coexist with a higher incidence of cardiovascular events. Patients selected in these studies included diabetic and non diabetic patients. In the placebo control group, isolated systolic hypertension in elderly patients with diabetes compared to patients with non-diabetic, major cardiovascular events, coronary heart disease events and the incidence of stroke and total mortality were significantly increased; and this association In the global study of different ethnic and geographical objects completely consistent. In the European Society of Cardiology 22nd session, there is a "high blood pressure and diabetes: life and death of the joint," the symposium, participants agreed that: diabetes, hypertension, insulin resistance and obesity are very clear links And this connection the development of cardiovascular disease is important. In all diabetic patients, about 80% died of cardiovascular disease, while more than half of type 2 diabetes, especially women, at age 50 high blood pressure can occur (if the person with diabetes, recently proposed to 130/86 mm Hg diagnostic criteria for hypertension). Cardiovascular disease is the major cause of death of diabetic patients with hypertension, in view of this, the Danish scholar Mogensen who the coexistence of hypertension and diabetes as the "double jeopardy in" crowd, that hypertension and diabetes is a deadly combination.
Diabetes and hypertension, kidney damage is also a target organ. Diabetic end-stage renal disease in the United States the most common cause, 63% of patients suffering from diabetic nephropathy of type 2 diabetes. Risk of mortality in patients with diabetic nephropathy extremely high mortality rate of almost 5 years up to 85%. Two studies on hypertension and renal disease (diabetes research-IDNTH Isa Betancourt and angiotensin receptor antagonist losartan reduces H end of the event study) found that, after being randomly assigned to conventional therapy (placebo) group patients, serum creatinine concentration was doubled, end stage renal disease and the high incidence of death. In the Irbesartan Microalbuminuria study of the kidney, the placebo control group with mild renal disease in hypertensive patients with diabetes within two years, the proportion of significant proteinuria is 15%.
In summary, hypertension with diabetes have a complex, multi-factor composition of pathophysiology, involving both large vessels and capillaries will be accelerated cardiovascular disease, stroke, kidney disease and retinopathy and its development and increase mortality. Active intervention and treatment of hypertension and diabetes, can significantly reduce the appearance of complications and mortality, to improve the patient's quality of life and prolonging life is of great significance.
In recent years, large clinical trial published in the report, such as systolic blood pressure of old age, systolic hypertension in Europe trial, hypertension optimal treatment trial of hypertension in diabetes study risk factors for acute myocardial infarction, etc., have been clearly demonstrated , diabetes and hypertension coexist with a higher incidence of cardiovascular events. Patients selected in these studies included diabetic and non diabetic patients. In the placebo control group, isolated systolic hypertension in elderly patients with diabetes compared to patients with non-diabetic, major cardiovascular events, coronary heart disease events and the incidence of stroke and total mortality were significantly increased; and this association In the global study of different ethnic and geographical objects completely consistent. In the European Society of Cardiology 22nd session, there is a "high blood pressure and diabetes: life and death of the joint," the symposium, participants agreed that: diabetes, hypertension, insulin resistance and obesity are very clear links And this connection the development of cardiovascular disease is important. In all diabetic patients, about 80% died of cardiovascular disease, while more than half of type 2 diabetes, especially women, at age 50 high blood pressure can occur (if the person with diabetes, recently proposed to 130/86 mm Hg diagnostic criteria for hypertension). Cardiovascular disease is the major cause of death of diabetic patients with hypertension, in view of this, the Danish scholar Mogensen who the coexistence of hypertension and diabetes as the "double jeopardy in" crowd, that hypertension and diabetes is a deadly combination.
Diabetes and hypertension, kidney damage is also a target organ. Diabetic end-stage renal disease in the United States the most common cause, 63% of patients suffering from diabetic nephropathy of type 2 diabetes. Risk of mortality in patients with diabetic nephropathy extremely high mortality rate of almost 5 years up to 85%. Two studies on hypertension and renal disease (diabetes research-IDNTH Isa Betancourt and angiotensin receptor antagonist losartan reduces H end of the event study) found that, after being randomly assigned to conventional therapy (placebo) group patients, serum creatinine concentration was doubled, end stage renal disease and the high incidence of death. In the Irbesartan Microalbuminuria study of the kidney, the placebo control group with mild renal disease in hypertensive patients with diabetes within two years, the proportion of significant proteinuria is 15%.
In summary, hypertension with diabetes have a complex, multi-factor composition of pathophysiology, involving both large vessels and capillaries will be accelerated cardiovascular disease, stroke, kidney disease and retinopathy and its development and increase mortality. Active intervention and treatment of hypertension and diabetes, can significantly reduce the appearance of complications and mortality, to improve the patient's quality of life and prolonging life is of great significance.
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