Drug Of Choice For The Treatment Of Juvenile Diabetes

As people's living standards improve and the people irrational diet, leading to more and more people started to suffer from diabetes, we often also see some children suffering from a minor disease, diabetes generally used in the treatment of people drug treatment, juvenile diabetes, how to choose that drug?

Select hypoglycemic drugs

Of children and adolescents also need to emphasize the treatment of diabetes diet, exercise, followed by selection of drug treatment. Juvenile diabetes, insulin or oral hypoglycemic agents can choose. Experts pointed out that the Juvenile Diabetes oral hypoglycemic agents with the selection and application of basic as adults, but the vast majority of oral hypoglycemic drugs in children and adolescents has not been done in a comprehensive and systematic safety studies, therefore, many oral drop sugar medication is not recommended or disable instructions in children and adolescents.

Preferred oral medication metformin

Experts, for the treatment of children and adolescents with type 2 diabetes drug is very limited, metformin was the first U.S. Food and Drug Administration (FDA) approved for the treatment of children and adolescents with juvenile diabetes, oral hypoglycemic agents, and the other drugs are Avandia (domestic sales of Avandia is still marked with instructions not recommended for children - publication note). Clinical use of metformin for many years, children and adolescents is safe and effective in type 2 diabetes, hypoglycemic agents, and its safety and effectiveness has been the medical field and patients around the world recognized, is the treatment of type 2 diabetes, children and adolescents preferred their oral sugar drugs, especially in the treatment of obese diabetic patients with significant effect.

Metformin in children and adolescents with diabetes in the dose calculation is based on use of this and is usually calculated according to the weight amount of children's medicine is different. Young children and adolescents using the appropriate dose in patients with small dose is started, according to the patient's individual situation, gradually increase the dose. Starting dose is 250 mg every 2 times a day taking a week to observe the condition, if not better, can increase the dose to 500 to 850 mg / time; for pediatric patients weighing more than 50kg, the dose of the beginning Adults can also use the recommended dose of 500 mg / time, 2 times a day. If accompanied by children and adolescents with diabetes high blood sugar (glucose> 13.9mmol / l) or ketosis, insulin therapy should be considered until the blood sugar stable, and back with oral hypoglycemic agents.

Other drugs need to be cautious

Insulin is the drug of choice for treatment of juvenile diabetes, in particular, glucose metabolism disorders in the acute and long-term toxicity of high blood sugar to produce high sugar, causing the surrounding tissue in children with diabetes, insulin resistance or type of difficulty, should use insulin, to achieve the ideal treatment.

The most serious side effect of sulfonylureas is low blood sugar will be produced, due to the growth and development of children in a period of low blood sugar on the brain development have a significant impact of the current recommended blood glucose control in 4 ~ 6mmol / L, glycosylated hemoglobin level control 6.5% ~ 7.0%, for children under 5 years old, this standard could be extended to prevent the occurrence of low blood sugar.

Generation sulfonylureas (such as Yamo Li) or non-sulfonylurea insulin secretagogues (such as repaglinide) and metformin combination therapy was better, can more easily control blood sugar, poor diet of young people on has a unique advantage. But these drugs are widely used in children, further safety studies.

Insulin sensitizers (glitazones) can diabetes in children and adolescents is also being studied in the application, the application of these drugs in long-term safety and effectiveness needs further confirmation.

α-glucosidase inhibitor because of its gastrointestinal side effects was not easily accepted by children and adolescents, use less, but studies have shown good safety of these drugs, and diabetes have some role in prevention.